The IGF-1 Trade-Off: Performance vs. Longevity

Speaking to your question about "what the long term effects of these drugs are": My wife put together a together a pretty interesting video about the "faustian bargain" which is IGF-1 (used as a proxy measure for growth hormone)... video is replete with examples of the effects of low IGF-1/GH or high IGF-1/GH both in animal models and humans. One of the more interesting points in the video is the fact that people with polymorphisms that make their IGF-1 receptor experience some slight loss of function actually live longer (in general). ▶ this video The video also links to an article which has a bibliography if you're interested.

in “What will it take to run a 2-hour marathon?” · View on HN

[link] [link] Its pretty well know mtor/igf-1 stimulates growth. All growth. This is great for youth. Not so much for aging. ▶ this video

in “Could cancer cells’ iron addiction be their Achilles heel?” · View on HN

1. Bigger groups === more and better data. I didn't know anyone growing up who was interested in ketogenic or carnivorous diets, now it's much more common. 2. Huge difference between the diet of a westerner following carnivore and traditional tribal carnivorous diets 3. The Inuits weren't particularly healthy, I'm not sure why their diet matters: [link] 4. And most importantly, there's a lot of research showing that high levels of IGF-1 associated with diets high in red meat are not good for longevity: ▶ this video

in “For 2M years, humans ate meat and little else: study” · View on HN