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The Problem with America’s Lab Mice and Why it Should Matter to You

The Problem with America’s Lab Mice and Why it Should Matter to You on HackerTube: recommended by 1 Hacker News commenter across 1 month, 2020–2021.

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A JRE clip in which Bret Weinstein explains his concern that most American lab mice descend from a single lab lineage. He argues this undermines how well mouse research translates to humans.

Why Hacker News recommends it

HN links it when discussing mouse-study reliability and reproducibility.

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discussed on HN
2020–2021
“Here's the actual segment (18 mins)”
— aaron695, Jul 2020, in “Cracking down on research fraud”

What HN commenters said

4 Hacker News comments link this video. Each one links back to its thread.

aaron695Jul 2020Recommends

He specifically mentions comments like yours are not helpful. This is the researcher fraud that is the problem in science that we are talking about, issues at hand are ignored or twisted so the paper mill can continue. The concept is all mice in the USA come from one laboratory and have a common attribute that's different from wild mice and European suppliers. And it's spelt out how in theory this different attribute could change medical results. To come back with we don't care, without proof it's not a issue, is a deeply broken system, but is exactly how current universities work. Here's the actual segment (18 mins) - ▶ this video Related (12 mins) - [link]

in “Cracking down on research fraud” · View on HN

LinuxBenderApr 2021Cites it

You may also need to buy that mouse from a specific lab for the therapies to have reproducible effects. [1] [1] - ▶ this video

in “Better drainage of brain debris improves Alzheimer's disease therapies” · View on HN

LinuxBenderNov 2020Cites it

There have been a few interviews with Bret Weinstein on this topic as it pertains to lab mice. [1] [2] I am curious if this is in any way related and would there be similar concerns around how humans deal with senescent cells and cancer if Telomere are artificially lengthened. Out of curiosity, does anyone in this field have more information to add to Bret's interview that can explain technically how the mice ended up with longer Telomere's and if it was on purpose? [1] - [link] [2] - ▶ this video

in “Human ageing process biologically reversed in world first” · View on HN

k2xlJul 2020Cites it

Ever since I watched Bret Weinstein explain the problem with using today's lab mice[1], I've been more cautious about any results involving mice and cancer. [1] ▶ this video

in “A combo of fasting plus vitamin C is effective for hard-to-treat cancers in mice” · View on HN

Topics & tags

Scientific method & science communicationBiology & biotechnologylab micebret weinsteinresearch reliabilityreproducibilitybiomedical research